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Is there a new drug to treat cannabis use disorder?

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작성자 dermamall 작성일19-02-15 16:34 조회428회 댓글0건



Is there a new drug to treat cannabis use disorder?

By Olajumoke Marissa Ologundudu - February 5, 2019 

In this study, researchers examined whether an inhibitor drug could be used to treat those suffering from cannabis withdrawal symptoms.


Cannabis is used worldwide and the trend continues to grow. A troubling issue is that cannabis use disorder can result from the use of the drug, especially if the individual uses more potent forms. Cannabis use disorder can lead to impaired behavior among other things and can also have debilitating withdrawal effects without recurrent use. Addiction may also occur. Once a person stops cannabis use for a short period of time, withdrawal can occur for about one to three weeks and can be accompanied by a whole host of other behaviors ranging from irritability to depression.

Treatment group used less cannabis, had better sleep, and scored better for anxiety and depression. Out of the 70 patients in the study, a total of 24 received the placebo and 46 received 4mg of PF-04457845. At the end of the four weeks, the treatment group had less reported cannabis use compared to the placebo, but thoughts of quitting cannabis did not seem to differ between the groups. Urine tests found less THC-COOH in the treatment group – an indicator of cannabis use – compared to the placebo.

Overall, in this study concerning cannabis use disorder, the researchers showed that there was some benefit to the use of the 4mg dose of PF-04457845, an FAAH inhibitor. PF-04457845 was shown to reduce a select number of withdrawal symptoms common in cannabis withdrawal and it seemed to reduce the use of cannabis itself in the treatment group compared to the placebo. In this study, there were no serious adverse events, suggesting that PF-04457845 seems to be safe.

Written by Olajumoke Marissa Ologundudu B.Sc. (Hons)

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